English language gives many variants how to say that someone is mad. Here I collected eight the most popular variants:
1.) She is not all there.
2.) He is off his trolley.
3.) He is not right in the head.
4.) She is got a screw loose.
5.) He is a basket case.
6.) He is off his rocker.
7.) She is one sandwich short of a picnic.
8.) He is as nutty as a fruitcake.